Effect of L-arginine on improvement of alveoli capillary wall thickness

Sri Sulistyowati (Department of Obstetrics and Gynecology, Faculty of Medicine, Sebelas Maret University, Surakarta)
Yasir Avisena (Department of Obstetrics and Gynecology, Faculty of Medicine, Sebelas Maret University, Dr Moewardi Hospital, Surakarta)
Supriyadi Hari R (Department of Obstetrics and Gynecology, Faculty of Medicine, Sebelas Maret University, Dr Moewardi Hospital, Surakarta)

Majalah Obstetri dan Ginekologi
Vol. 25 No. 1 (2017): April

Objectives: This study aims to demonstrate the effect of L-Arginine on pulmonary edema on mice preeclampsia model.Materials and Methods: This experimental analytic study was conducted on 30 pregnant mice divided into 3 groups, namely 10 normal pregnant mice (K1), 10 pregnant mice preeclampsia model (K2), and 10 pregnant mice pre-eclampsia model who received L-Arginine (K3) therapy. All subjects examined the thickness of the alveoli capillary wall in their pulmo using the Immunohisto-chemical method. The results were analyzed using Kruskal Wallis and Mann Whiteney tests.Results:  Average alveoli capillary wall thickness (K1) 5.01±1.76/µm, (K2) 11.57±7.11/µm, with p value=0.00. Average alveoli capillary wall thickness (K3) 7.90±4.10/µm with p value=0.01.Conclusion: L-arginine affects to improve pulmonary edema in preeclampsia by reducing alveoli capillary wall thickness of the pulmonary in mice model.