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All Journal Majalah Obstetri dan Ginekologi
Supriyadi Hari R
Department of Obstetrics and Gynecology, Faculty of Medicine, Sebelas Maret University, Dr Moewardi Hospital, Surakarta
Health Professions Medicine & Pharmacology

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Effect of L-arginine on improvement of alveoli capillary wall thickness Sri Sulistyowati; Yasir Avisena; Supriyadi Hari R
Majalah Obstetri dan Ginekologi Vol. 25 No. 1 (2017): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.831 KB) | DOI: 10.20473/mog.V25I12017.25-29

Abstract

Objectives: This study aims to demonstrate the effect of L-Arginine on pulmonary edema on mice preeclampsia model.Materials and Methods: This experimental analytic study was conducted on 30 pregnant mice divided into 3 groups, namely 10 normal pregnant mice (K1), 10 pregnant mice preeclampsia model (K2), and 10 pregnant mice pre-eclampsia model who received L-Arginine (K3) therapy. All subjects examined the thickness of the alveoli capillary wall in their pulmo using the Immunohisto-chemical method. The results were analyzed using Kruskal Wallis and Mann Whiteney tests.Results:  Average alveoli capillary wall thickness (K1) 5.01±1.76/µm, (K2) 11.57±7.11/µm, with p value=0.00. Average alveoli capillary wall thickness (K3) 7.90±4.10/µm with p value=0.01.Conclusion: L-arginine affects to improve pulmonary edema in preeclampsia by reducing alveoli capillary wall thickness of the pulmonary in mice model.
Co-Authors Sri Sulistyowati Yasir Avisena