<![CDATA[Background: Hypertension is related to high blood pressure, with values above 140/80 mm Hg, and is a major contributor to morbidity in Indonesia. Pharmacotherapy is recommended for patients with high-grade hypertension and can be administered as monotherapy or combination therapy. Angiotensin-converting enzyme inhibitors (ACEIs), such as captopril, and calcium channel blockers (CCBs), such as amlodipine, were among the most prescribed combination therapies. Case reports suggest that ACEIs are associated with hypoglycemia, whereas CCBs are associated with hyperglycemia. However, no studies related to blood glucose show results in combining use. Objective: This study aimed to test the effect of ACEI and CCB combination on blood glucose levels in Sprague-Dawley rats. Methods: Twenty-five Sprague-Dawley rats (6-8 weeks old) were divided into 5 groups of 5 animals each consisting of normal, negative control, amlodipine, captopril, and combination group. The test lasted for 21 days, and blood glucose levels were measured every 7 days. The significance level was set at p-value<0.05 to determine whether there was an effect on blood glucose. Results: There were significant differences in blood glucose levels before and after treatment in the amlodipine and combination groups with significance levels, respectively, p=0.003; 0.046 (p<0.05). Conclusion: Among all test groups, amlodipine showed a significant results in affecting blood glucose and resulting in hyperglycemic events. While the combination showed a significant difference, it did not lead to hyperglycemia.]]>
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