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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Health Information : Jurnal Penelitian
Mulianingtyas, Grace Valentina
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Chemistry Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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The Occurrence of Stunting during The COVID-19 Pandemic at Integrated Health Center: An Observational Study in Mekarjaya, Depok, West Java Putri, Salsabila Auni; Maskunah, Maskunah; Riyanti, Riyanti; Mulianingtyas, Grace Valentina; Suhendra, Faiza Assyifa; Octavia, Lestari
Health Information : Jurnal Penelitian Vol 15 No 2 (2023): Mei-Agustus
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v15i2.921

Abstract

Pandemi COVID-19 dapat meningkatkan tantangan pemenuhan zat gizi, terutama untuk kelompok balita di negara dengan kondisi karakteristik dengan pendapatan rendah-mencegah termasuk Indonesia. Gangguan infeksi pada anak-anak, termasuk balita dapat diperburuk oleh kejadian malnutrisi dan berkontribusi pada kemungkinan transmisi virus SARS-CoV-2.  Posyandu menjadi ujung tombak dalam program pemantauan status gizi balita, termasuk di masa pandemi. Pada penelitian ini bertujuan untuk mengidentifikasi status gizi pada balita saat pandemi covid-19 di Pos Pelayanan Terpadu (Posyandu) “Kuntum Mekar A RW 21” di Mekarjaya, Kota Depok, Jawa Barat. Metode penelitian ini menggunakan data sekunder dari kegiatan penimbangan balita yakni: tinggi/panjang badan, jenis kelamin, dan usia. Hasil penelitian dengan total jumlah subjek 135 balita yang data hasil pengukurannya dapat diolah. Subyek terdiri dari 1 bayi baru lahir (0-3 bulan) yang tidak mengalami kategori stunting, 27 anak (4-12 bulan) dengan persentase stunting 7,4% dan stunting parah 3,7%, 31 balita (usia 13-23 bulan) dengan persentase stunting 12,9% dan stunting parah 3,2%. Dua puluh tujuh anak usia (24-35 bulan) persentase stunting 14,8%, 22 anak usia (36-47 bulan) persentase stunting 22,7% dan stunting parah 4,5%, dan untuk kelompok umur 47-59 bulan, 27 anak, persentase stunting 14,8%. Total prevalensi stunting di wilayah kerja Posyandu Kuntum Mekar A RW 21 Mekarjaya, Depok adalah 16,3%. Pendekatan penanganan stunting memerlukan kerjasama multisektor dan berkelanjutan untuk menciptakan generasi emas tahun 2045.
Effect of Combined Angiotensin-Converting Enzyme Inhibitor and Calcium Channel Blocker Therapy on Blood Glucose Level in Sprague-Dawley Rats Mulianingtyas, Grace Valentina; Nainggolan, Hotlina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.399-406

Abstract

Background: Hypertension is related to high blood pressure, with values above 140/80 mm Hg, and is a major contributor to morbidity in Indonesia. Pharmacotherapy is recommended for patients with high-grade hypertension and can be administered as monotherapy or combination therapy. Angiotensin-converting enzyme inhibitors (ACEIs), such as captopril, and calcium channel blockers (CCBs), such as amlodipine, were among the most prescribed combination therapies. Case reports suggest that ACEIs are associated with hypoglycemia, whereas CCBs are associated with hyperglycemia. However, no studies related to blood glucose show results in combining use. Objective: This study aimed to test the effect of ACEI and CCB combination on blood glucose levels in Sprague-Dawley rats. Methods: Twenty-five Sprague-Dawley rats (6-8 weeks old) were divided into 5 groups of 5 animals each consisting of normal, negative control, amlodipine, captopril, and combination group. The test lasted for 21 days, and blood glucose levels were measured every 7 days. The significance level was set at p-value<0.05 to determine whether there was an effect on blood glucose. Results: There were significant differences in blood glucose levels before and after treatment in the amlodipine and combination groups with significance levels, respectively, p=0.003; 0.046 (p<0.05). Conclusion: Among all test groups, amlodipine showed a significant results in affecting blood glucose and resulting in hyperglycemic events. While the combination showed a significant difference, it did not lead to hyperglycemia.
Co-Authors Maskunah, Maskunah Nainggolan, Hotlina Octavia, Lestari Putri, Salsabila Auni Riyanti Riyanti Suhendra, Faiza Assyifa