<![CDATA[Human Papillomavirus (HPV) infection remains the leading cause of cervical cancer and continues to pose a public health problem in Indonesia. While previous studies have widely examined HPV-related knowledge and vaccines acceptance, evidence focusing on early adolescents within school-based vaccination settings remain limited. This study aims to analyze the relationship between the level of knowledge and acceptance of the HPV vaccine among third-grade junior high school students, a key target group for national immunization programs. A cross-sectional quantitative design was conducted among 48 students selected through total sampling. Data were collected using a structured questionnaire that measured respondent characteristics, knowledge levels about HPV, and acceptance of the HPV vaccine. Data analysis was performed univariately and bivariately using Fisher's Exact test with a significance level of 0.05. Most respondents were aged 14 years (60.4%), had high knowledge about HPV (72.9%), and showed positive acceptance of the HPV vaccine (64.6%). Bivariate analysis showed that students with high knowledge were 1.14 times more likely to accept the HPV vaccine positively than students with poor to moderate knowledge. However, this relationship was not statistically significant (p = 0.731; PR = 1.14; 95% CI: 0.67–1.94). There was no significant relationship between students' level of knowledge about HPV and their acceptance of the HPV vaccine. The study highlights the need for multidimensional intervention strategies involving parental engagement, school support, and health worker communication.]]>
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