This study aims to analyze the influence of physical and mental workload on the implementation of patient safety at Jannah Hospital, Serang City, with Organizational Citizenship Behavior (OCB) as a mediator variable. The research method used was quantitative with a cross-sectional design. Data were collected through questionnaires distributed to 89 respondents using a simple random sampling technique. Data analysis was performed using the Chi-square test and path analysis using SmartPLS software. The results showed that physical workload had a negative and significant effect on the implementation of patient safety (p = 0.002; coefficient -0.247). Conversely, mental workload did not show a significant effect on patient safety (p = 0.146; coefficient -0.135). Simultaneously, physical and mental workload influenced patient safety with an R-square value of 0.343. Furthermore, OCB was shown to significantly mediate the relationship between physical workload and patient safety (p = 0.047; coefficient –0.106), but OCB's mediation of the relationship between mental workload and patient safety was not significant (p = 0.280; coefficient –0.079). Based on these findings, the study recommends managing physical and mental workload through stress management programs, establishing a more balanced work schedule, and improving communication and collaboration between nurses. Furthermore, it is important to strengthen a work culture that supports OCB and rewards extra-role behavior. Further research with a larger sample size and additional variables such as organizational support and job satisfaction is recommended to gain a more comprehensive understanding of the influence of workload on patient safety.
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