African Journal of Biochemistry and Molecular Biology Research
Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research

Ameliorative Effects of Stem bark Extract of Pterocarpus erinaceus on Indomethacin-induced Ulcer

Isaac John Umaru (Unknown)
Otitoju Olawale (Unknown)
Emmanuel Chikodiri Okoli (Unknown)
Akafa Andes Tensaba (Unknown)
Kerenhappuch Isaac Umaru (Unknown)
Dafup Kadel Istifanus (Unknown)
David Umahi (Unknown)



Article Info

Publish Date
28 Jul 2024

Abstract

Pterocarpus erinaceus serve as a medicinal plant to many populations of Nigeria and West Africa. The stem bark, leaves, and root bark have been studied for their antioxidant, antimalaria, antiulcerogenic, and antibacterial properties. The study examined the anti-ulcerogenic properties of Pterocarpus erinaceus stem bark extracts in albino rats with indomethacin-induced ulcers and hepatic biochemical changes. The anti-ulcer effect was determined by histopathological examination of ulcerated rats treated with the stem bark extracts in a period of 14-days. The three extracts did not cause elevation of key liver biomarkers such as AST, ALT, and ALP. Hence are considered not non-toxic at the dose and duration given. The leaf extract exhibited anti-ulcer effect at 100, 200, and 300 mg/kg.

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Journal Info

Abbrev

AJBMBR

Publisher

Subject

Biochemistry, Genetics & Molecular Biology

Description

African Journal of Biochemistry and Molecular Biology Research aims to publish high-quality, peer-reviewed research that advances biochemical and molecular understanding of living systems while supporting interdisciplinary developments across the life sciences. • Biochemical Advancement: ...