Makara Journal of Science
Vol. 30, No. 1

Comparative Antiscabies Efficacy of Sonneratia alba Extracts: Evaluation of Plant Parts and Concentrations in Mice

Maretha, Delima Engga (Unknown)
Taresha, Lara Mukti (Unknown)
Yuliana, Karina (Unknown)
Ariska, Iis (Unknown)
Lestari, Silvia Diah (Unknown)



Article Info

Publish Date
30 Mar 2026

Abstract

This study evaluated the antiscabies efficacy of 70% ethanol extracts from various parts of the mangrove Sonneratia alba (leaves, flowers, bark, and roots) as a potential alternative therapy. The primary objective was to compare the healing effects of the extracts at different concentrations on scabies lesions in mice (Mus musculus). Using a completely randomized design, 24 male Swiss Webster mice were assigned to four groups: a control (K0) group and three treatment groups to receive 10% (K1), 20% (K2), and 30% (K3) extract concentrations topically twice daily. The results demonstrated that the S. alba extracts had significant effects on lesion healing (p < 0.05). The leaf and root extracts exhibited optimal efficacy at a 10% concentration, whereas the bark and flower extracts were the most effective at 30% concentration. These findings suggest that S. alba extracts, particularly those from leaves and roots, hold significant promise as a novel plant-based treatment for scabies, warranting further research into their potential clinical applications.

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Journal Info

Abbrev

publication:science

Publisher

Subject

Description

Makara Journal of Science publishes original research or theoretical papers, notes, and minireviews on new knowledge and research or research applications on current issues in basic sciences, namely: Material Sciences (including: physics, biology, and chemistry); Biochemistry, Genetics, and ...