<![CDATA[ABSTRACT. Polymers have become essential excipients in pharmaceutical formulations, significantly enhancing drug delivery systems due to their versatility, biocompatibility, and specialized properties. This review discusses the role of natural and synthetic polymers, which are favored for their biodegradability and ability to improve drug stability and controlled release. The paper highlights innovations in polymer-based drug delivery, including the development of stimuli-responsive polymers that release drugs in response to specific environmental triggers and the integration of natural and synthetic polymers to create hybrid systems. Despite the advantages, challenges such as variability in natural polymer sources, potential toxicity of synthetic polymers, and regulatory hurdles remain. Future prospects include advancements in green and sustainable polymers, personalized medicine, and the use of nanotechnology to enhance drug delivery efficacy. This comprehensive examination underscores the importance of interdisciplinary research in overcoming existing barriers and advancing polymer-based drug delivery systems to improve patient outcomes. Keywords:Polymer, Drug delivery, Natural polymer, Synthetic polymer, Stimuli-responsive]]>
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