<![CDATA[A previous study reported that Kaempferia galanga L. (K. galanga) has anti-inflammatory and antioxidant activity. However, the research about how Kaemferia galanga L. inhibits lipid peroxidation (LPOI) has been limited. This study aimed to determine the physicochemical properties of the ethyl acetate fraction of K. galanga (EAFK) and its lipid peroxidation inhibitory activity. The anatomical structure of the rhizome was observed using a light microscope and scanning electron microscopy (SEM). Microelement analysis was determined by SEM-Energy Dispersive X-Ray Spectroscopy (SEM-EDX) mapping. The 70% ethanol extract of K. galanga was fractionated by a liquid-liquid technique using ethyl acetate. Phytochemical, the total phenolic and flavonoid levels, ethyl-p-methoxycinnamate (EPMC) as a marker compound, the specific and non-specific parameters of the fraction were determined. The antioxidant activity was evaluated using DPPH and LPOI assays. The results showed that the rhizome of K. galanga has oil cells, and the powder contains microelements. The EPMC level in the EAFK was 0.66 % (w/w). At concentrations of 4000 ppm and 625 ppm, the EAFK could inhibit 15.90%±0.35 of DPPH free radical scavenging and 17.43%±6.52 of lipid peroxidation, respectively. Based on these findings, K. galanga contains microelements, EPMC, and the EAFK has an antioxidant effect via inhibiting lipid peroxidation and antiradical activity.]]>
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