Management of Type 2 Diabetes Mellitus (T2DM) as a chronic pathology highly depends on the synergy between pharmacological interventions and lifestyle modifications. Patient health literacy plays a crucial role in determining the effectiveness of glycemic control and the prevention of long-term complications. This research aims to map the patient knowledge profile while identifying the determinant factors influencing it at Royal Prima Hospital, Medan. Utilizing a descriptive quantitative design with a cross-sectional approach, this study involved 100 respondents recruited through an accidental sampling technique. The research instrument employed an adapted version of the DKQ-24 questionnaire. Univariate analysis results confirmed that the majority of respondents (79%) possessed adequate understanding regarding their treatment regimen. Based on the Chi-Square test, a significant correlation was found in the gender variable ($p = 0.044$), while other demographic and clinical variables showed no meaningful association. Furthermore, binary logistic regression testing demonstrated a lack of simultaneous influence from all independent variables on the level of patient knowledge.
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