<![CDATA[Porphyromonas gingivalis is the main bacteria that causes periodontitis, and the use of antibiotics such as metronidazole can cause side effects and resistance. Andrographolide from the bitter plant is a natural alternative that has potential as an antibacterial. This study aims to evaluate the antibacterial activity of Andrographolide against P. gingivalis using the disc diffusion method at concentrations of 6 mg/mL, 8 mg/mL, and 10 mg/mL. Metronidazole 0.5 mg/mL was used as a positive control and 96% ethanol as a negative control. The results showed that Andrographolide concentrations of 6 mg/mL and 8 mg/mL produced a moderate inhibition zone, while a concentration of 10 mg/mL produced a strong inhibition zone. This study concluded that Andrographolide has antibacterial activity against P. gingivalis and shows an increase in inhibition with increasing concentration. ]]>
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