Jurnal teknologi Kesehatan Borneo
Vol 7 No 1 (2026): Jurnal teknologi Kesehatan Borneo

Acute Antihyperglycemic Activity of Kepok Banana Blossom (Musa paradisiaca L.) Extract in Mice

Rini Handayani (Department of Pharmacy Health Polytechnic of Aceh Ministry of Health, Aceh, Indonesia)
Rasidah (Department of Pharmacy Health Polytechnic of Aceh Ministry of Health, Aceh, Indonesia)
Munira (Department of Pharmacy Health Polytechnic of Aceh Ministry of Health, Aceh, Indonesia)
Noni Zakiah (Department of Nutrition Health Polytechnic of Aceh Ministry of Health, Aceh, Indonesia)
Agus Hendra Al Rahmad (Department of Nutrition Health Polytechnic of Aceh Ministry of Health, Aceh, Indonesia)



Article Info

Publish Date
28 Jul 2026

Abstract

Banana inflorescence contains phytochemicals that may modulate postprandial glucose, but evidence for freshly prepared Kepok banana blossom is limited. This exploratory animal study evaluated the acute antihyperglycemic activity of 40%, 50%, and 60% fresh Kepok banana blossom (Musa paradisiaca L.) preparations using an oral glucose tolerance test. Twenty-five male mice were randomly allocated to distilled-water control, metformin control, or three extract groups (n = 5/group). Following fasting and oral glucose loading, blood glucose was measured before and after loading and at 30, 60, and 120 minutes after intervention. Qualitative screening detected alkaloids, saponins, flavonoids, phenolics, and tannins. At 120 minutes, mean glucose levels were 169.0 mg/dL in the negative control, 123.6 mg/dL with metformin, and 121.0, 136.6, and 125.0 mg/dL with the 40%, 50%, and 60% preparations, respectively. Descriptive mean-curve AUC values were 23,457, 18,525, 19,308, 19,650, and 19,740 mg/dL·min. These results suggest that fresh Kepok banana blossom preparations attenuated the acute glucose excursion compared with distilled water. However, the small sample, qualitative-only phytochemistry, nonstandardized dosing, and absence of a chronic diabetes model preclude conclusions about equivalence among concentrations, mechanism, or antidiabetic efficacy

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Journal Info

Abbrev

JTKB

Publisher

Subject

Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

Description

Jurnal teknologi Kesehatan Borneo is published by the Poltekkes Kemenkes Pontianak, managed by the Pontianak Ministry of Health Research and Community Service Center for Health Poltekkes. Jurnal teknologi Kesehatan Borneo is an open-access journal with timely Peer Reviews in the health sciences. ...