<![CDATA[Nurses occupy a strategic position in hospital service quality due to their intensive, continuous interaction with patients, yet high workloads in complex healthcare settings often threaten their psychological wellbeing and job satisfaction. This study aims to examine the influence of resilience and social support on nurses' job satisfaction at RS YARSI Central Jakarta, with sleep quality and mental support serving as mediating variables, and to test twelve hypotheses derived from these relationships. A quantitative approach with a cross-sectional design was employed, using Partial Least Squares Structural Equation Modeling (PLS-SEM) analyzed through SmartPLS 4.0. Data were collected from 160 active nurses selected through purposive sampling via a structured Likert-scale questionnaire measuring resilience, social support, sleep quality, mental support, and job satisfaction. The results show that resilience and social support each have a positive and significant effect on job satisfaction, sleep quality, and mental support. Mental support significantly mediates the relationship between resilience and job satisfaction, as well as between social support and job satisfaction. However, sleep quality does not significantly mediate either relationship, nor does it show a significant direct effect on job satisfaction, indicating that psychosocial pathways are more dominant than physiological ones in shaping nurses' job satisfaction in this context. These findings suggest that hospital management should prioritize strengthening resilience-building programs and workplace mental support systems—such as supervisory communication, peer support, and psychological counseling—over relying solely on sleep-related interventions to enhance nurses' job satisfaction and, ultimately, retention and service quality at RS YARSI.]]>
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