<![CDATA[Extracting clinical entities such as signs, symptoms, diagnoses, and treatments from Indonesian clinical research makes clinical information more accessible to readers with varying levels of medical knowledge. Conditional Random Fields (CRFs) combined with hand-engineered features have proved effective for health domain named entity recognition (NER). However, studies comparing hand-engineered feature combinations for clinical NER in Indonesian clinical research articles remain limited. This study compares five hand-engineered feature combinations using a CRF model to identify the most effective combination for recognizing seven clinical entity types, using a newly annotated corpus of 29 Indonesian internal medicine research articles. The dataset was split into 80% training and 20% testing data. Model performance was evaluated using weighted-average and macro-average precision, recall, and F1-score, reported as mean ± SD across five random states (5, 10, 15, 20, 25) and training epochs (50, 100, 150). The combination of contextual, prefix and suffix, and orthographic features achieved the best weighted F1-score of 78.90% at Epoch 50, though macro-F1 was considerably lower at 64.32%, reflecting weaker performance on minority entity types. This gap indicates a need for further corpus expansion and data balancing.]]>
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