Phagocytosis Effectivity Test of Phenylbutenoid Compounds Isolated from Bangle (Zingiber cassumunar Roxb.) Rhizome

CHAIRUL CHAIRUL (Laboratory of Natural Product, Botany Division, Research Center for Biology, Indonesian Institute for Sciences (LIPI), Cibinong 16911.)
PRAPTIWI PRAPTIWI (Laboratory of Natural Product, Botany Division, Research Center for Biology, Indonesian Institute for Sciences (LIPI), Cibinong 16911.)
SOFNIE MARUSIN CHAIRUL (Center for the Application of Isotope and Radiation Technology, National Nuclear Energy Agency (BATAN), Jakarta,12440.)

Biodiversitas Journal of Biological Diversity
Vol. 10 No. 1 (2009)

This study was conducted to determine the immunostimulant activity of several phenylbutenoid derivatives isolated frombangle (Zingiber cassumunar Roxb) rhizome: [1] [(E)-4-(3’,4’-dimethoxyphenyl)but-3-en-1-ol], [2] [(E)-4-(2’,4’,5’ trimethoxyphenyl) but-3-en-1-ol] and [3] [(E)-4-(3’,4’,1-trimethoxyphenyl)but-3-en-1-ol]. Immunostimulant activity was done by stimulating macrophage cells of mouse peritoneum. The result showed that [(E)-4-(3’,4’-dimethoxyphenyl)but 3-en-1-ol] compound had highest immunostimulant activity (99.0%) compared to compound 2 (93.7%) and 3 (80.0%).Key words: Zingiber cassumunar Roxb, immunostimulant, phenylbutenoid derivative, [(E)-4-(3’,4’-dimethoxyphenyl)but-3-en-1-ol], [(E)-4-(2’,4’,5’-trimethoxyphenyl)but-3-en-1-ol]and [(E)-4-(3’,4’,1-trimethoxy phenyl)but-3-en-1-ol