Efektivitas Krim Ekstrak Kulit Buah Pisang Kepok (Musa paradisiaca L.) Terhadap Penyembuhan Luka Sayat Mencit (Mus musculus)

Fauziah Fauziah (Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Syiah Kuala, Aceh, Indonesia Program Doktor Matematika dan Aplikasi Sains, Universitas Syiah Kuala, Banda Aceh, Indonesia)
Laila Selfiana (Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Syiah Kuala, Aceh, Indonesia)
Dalil Sutekad (Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Syiah Kuala, Aceh, Indonesia)
Yulia Sari Ismail (Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Syiah Kuala, Aceh, Indonesia)

Jurnal Bioleuser
Vol. 10 No. 1: April 2026

The peel of the kepok banana (Musa paradisiaca L.) has been found to contain bioactive compounds that have the potential to accelerate wound healing. The objective of this study was to ascertain the efficacy of a cream formulated from kepok banana peel extract in the healing of incision wounds in mice (Mus musculus). The present study employed a completely randomised design (CRD), with 21 mice divided into seven treatment groups: control cream, sulfadiazine, and banana peel extract cream at concentrations of 3%, 6%, 9%, 12%, and 15%. The treatment was administered for a period of seven days, after which the thickness of the epithelial layer and the density of collagen were measured. The data were analysed using a one-way analysis of variance (ANOVA) and Duncan's test. The results demonstrated that the banana peel extract cream had a significant effect on wound healing (p<0.05). The greatest epithelial thickness was observed at a 3% concentration (69.42 ± 4.45 µm), while the highest collagen density was observed at a 15% concentration (44.10 ± 1.80%). The study concluded that banana peel extract cream is effective in accelerating the healing of incision wounds in mice.