Sex, Brinkman Index, And Pleural Glucose Levels As Predictors Of Pleurodesis Outcome In Malignant Pleural Effusion: Evidence From Rsud Jenderal Ahmad Yani Metro (2023–2024)

Fransisca TY Sinaga (Program Studi Pendidikan Kedokteran, Fakultas Kedokteran , Universitas Malahayati, Lampung, Indonesia & Departemen Pulmonologi dan Respirasi, Fakultas Kedokteran, Universitas Lampung, Rumah Sakit Dr. H. Abdul Moeloek Lampung, Indonesia)
Fitriyah Shahab (Program Studi Pendidikan Kedokteran, Fakultas Kedokteran, Universitas Malahayati, Lampung, Indonesia & Departemen Pulmonologi dan Respiratory, Rumah Sakit BARI, Palembang, Indonesia)
Achmad Gozali (Program Studi Pendidikan Kedokteran, Fakultas Kedokteran, Universitas Malahayati, Lampung, Indonesia)
Retno Ariza S Soemarwoto (Program Studi Pendidikan Kedokteran, Fakultas Kedokteran, Universitas Malahayati, Lampung, Indonesia)
Muhammad Junus Didiek Herdarto (Program Studi Pendidikan Kedokteran, Fakultas Kedokteran, Universitas Malahayati, Lampung, Indonesia)
Andreas Infianto (Program Studi Pendidikan Kedokteran, Fakultas Kedokteran, Universitas Malahayati, Lampung, Indonesia & Departemen Pulmonologi dan Respiratory, Rumah Sakit BARI, Palembang, Indonesia)
Apri Lyanda (Program Studi Pendidikan Kedokteran, Fakultas Kedokteran, Universitas Malahayati, Lampung, Indonesia)
Hidayat Hidayat (Program Studi Pendidikan Kedokteran, Facultas Kedokteran, Universitas Malahayati, Lampung, Indonesia)

Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Vol 20 No 1 (2026): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)

Malignant pleural effusion (MPE) is a frequent complication of advanced adenocarcinoma, leading to dyspnea and impaired quality of life. Pleurodesis is the standard palliative approach, but outcomes vary. This study evaluated the association of sex, smoking exposure (Brinkman Index), and pleural glucose with pleurodesis success. An observational analytic study was conducted at RSUD Jenderal Ahmad Yani Metro, Lampung, from July 2023 to July 2024. Thirty-eight patients with adenocarcinoma-related MPE were recruited; six were excluded, leaving 32 eligible subjects who underwent bleomycin pleurodesis. Outcomes were categorized as complete response (CR), partial response (PR), or failure. Associations between predictive factors and pleurodesis outcomes were analyzed using the Chi-Square test. Pleurodesis success correlated significantly with sex (p = 0.042), Brinkman Index (p = 0.027), and pleural glucose (p < 0.001). Females achieved higher CR rates (53.8%) than males (15.8%). Lower Brinkman Index values were linked to better outcomes, while pleural glucose >60 mg/dL strongly predicted success. Conclusion: Sex, smoking exposure, and pleural glucose may predict pleurodesis outcomes in adenocarcinoma-related MPE. Female sex, lower smoking burden, and higher pleural glucose were associated with improved pleural adhesion, supporting their role in guiding treatment.