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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Achmad Gozali
Program Studi Pendidikan Kedokteran, Fakultas Kedokteran, Universitas Malahayati, Lampung, Indonesia
Health Professions Medicine & Pharmacology

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Sex, Brinkman Index, And Pleural Glucose Levels As Predictors Of Pleurodesis Outcome In Malignant Pleural Effusion: Evidence From Rsud Jenderal Ahmad Yani Metro (2023–2024) Fransisca TY Sinaga; Fitriyah Shahab; Achmad Gozali; Retno Ariza S Soemarwoto; Muhammad Junus Didiek Herdarto; Andreas Infianto; Apri Lyanda; Hidayat Hidayat
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 20 No 1 (2026): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v20i1.12348

Abstract

Malignant pleural effusion (MPE) is a frequent complication of advanced adenocarcinoma, leading to dyspnea and impaired quality of life. Pleurodesis is the standard palliative approach, but outcomes vary. This study evaluated the association of sex, smoking exposure (Brinkman Index), and pleural glucose with pleurodesis success. An observational analytic study was conducted at RSUD Jenderal Ahmad Yani Metro, Lampung, from July 2023 to July 2024. Thirty-eight patients with adenocarcinoma-related MPE were recruited; six were excluded, leaving 32 eligible subjects who underwent bleomycin pleurodesis. Outcomes were categorized as complete response (CR), partial response (PR), or failure. Associations between predictive factors and pleurodesis outcomes were analyzed using the Chi-Square test. Pleurodesis success correlated significantly with sex (p = 0.042), Brinkman Index (p = 0.027), and pleural glucose (p < 0.001). Females achieved higher CR rates (53.8%) than males (15.8%). Lower Brinkman Index values were linked to better outcomes, while pleural glucose >60 mg/dL strongly predicted success. Conclusion: Sex, smoking exposure, and pleural glucose may predict pleurodesis outcomes in adenocarcinoma-related MPE. Female sex, lower smoking burden, and higher pleural glucose were associated with improved pleural adhesion, supporting their role in guiding treatment.
Co-Authors Andreas Infianto Apri Lyanda Fitriyah Shahab Fransisca TY Sinaga Hidayat Hidayat Muhammad Junus Didiek Herdarto Retno Ariza S Soemarwoto