The state of science education in Grade V at SDN 105855 PTPN II Tanjung Morawa indicates that students' scientific literacy remains low, and there is limited use of instructional media that connect scientific concepts with everyday realities. Consequently, students have not fully grasped the interrelationships among science, the environment, technology, and social contexts within daily life. This study employed a Research and Development (R&D) approach utilising the ADDIE model—comprising the stages of Analysis, Design, Development, Implementation, and Evaluation. The trial involved 25 students from class VA. Findings reveal that the designed instructional material achieved excellent validity ratings. Expert assessments recorded validity scores of 92.42% from the subject matter expert, 84.33% from the media expert, and 80.00% from the language expert. Regarding practicality, feedback from both teachers and students fell into the "highly practical" category, with scores of 91.11% and 92%, respectively. Meanwhile, effectiveness testing demonstrated a significant increase in students' average scores, rising from 48.00 in the initial evaluation to 88.00 in the final evaluation. The N-Gain calculation yielded a mean score of 0.7806, falling within the high-level category. Furthermore, a one-sample t-test analysis produced a significance value of 0.000 (less than 0.05), leading to the rejection of the null hypothesis (H0) and the acceptance of the alternative hypothesis (Ha). Ultimately, the SETS-based science instructional material covering the digestive system proved to be valid, practical, and effective in enhancing the scientific literacy skills of elementary school students.
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