This study aims to analyze the effect of human development quality, economic growth, and unemployment on poverty levels in Keerom Regency during the period 2011–2021. The research employs a quantitative approach using path analysis based on secondary data obtained from Statistics Indonesia (BPS). The results show that economic growth has a significant effect on the Human Development Index (HDI), but does not have a significant effect on unemployment. Furthermore, both HDI and economic growth have a significant effect on poverty levels, while unemployment does not have a significant effect. Indirectly, economic growth also influences poverty through HDI as an intervening variable. These findings indicate that improving the quality of human development is a key factor in reducing poverty, therefore development policies should prioritize sustainable human resource development. Keywords: poverty, human development index, economic growth, unemployment
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