Potensi Leunca (Solanum nigrum L.) sebagai Antiobesitas pada Tikus yang Diinduksi Diet Tinggi Lemak dan Sukrosa

Sekar Ayu Putri Gunawan (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Nurhanifah Muthmainnah Nurdin (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Gemala Anjani (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Siti Fatimah Muis (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Etika Ratna Noer (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Fitriyono Ayustaningwarno (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)

Amerta Nutrition
Vol. 10 No. 3 (2026): AMERTA NUTRITION (Bilingual Edition)

Background: Long-term consumption of high-calorie foods can lead to obesity. Leunca fruit contains several phytochemicals that act as antioxidants and anti-obesity agents. Objectives: This study aims to analyze the potential of Solanum nigrum fruit as an anti-obesity agent in rats induced with a high-fat sucrose diet (HFSD) to prevent weight gain. Methods: This study was experimental. The sample consisted of 30 male Sprague -Dawley rats, divided into 5 groups: K1 (standard diet), K2 (HFSD), P1 (HFSD + leunca 0.8 g/200 gBW), P2 (HFSD + leunca 1.6 g/200 gBW), and P3 (HFSD + leunca 2.4 g/200 gBW). The study was conducted at the Nutrition Laboratory, Center for Food and Nutrition Studies, Gadjah Mada University (PSPG PAU UGM), Yogyakarta, from January to March 2024. Results: This study was experimental. The sample consisted of 30 male Sprague -Dawley rats, divided into 5 groups: K1 (standard diet), K2 (HFSD), P1 (HFSD + leunca 0.8 g/200 gBW), P2 (HFSD + leunca 1.6 g/200 gBW), and P3 (HFSD + leunca 2.4 g/200 gBW). The study was conducted at the Nutrition Laboratory, Center for Food and Nutrition Studies, Gadjah Mada University (PSPG PAU UGM), Yogyakarta, from January to March 2024. Conclusions: Components such as fiber, antioxidants, vitamin A, vitamin C, flavonoids, and tannins contained in leunca fruit have an anti-obesity effect. Leunca fruit at a dose of 1,6 g/200 gBW and 2,4 g/200 gBW is the most effective dose in preventing weight gain in rats induced by a high-fat sucrose diet.