<![CDATA[Background: Surgical Site Infections (SSIs) are postoperative infections categorized into superficial, deep, and organ/ space infections, mostly caused by endogenous bacteria. Silver sulfadiazine as topical antimicrobial are widely used, though its effectiveness in SSIs remains unproven. Current research focuses on its impact on lymphocyte and collagen levels in animal models to better understand its role in SSI management. Objective: This study aimed to verify the use of silver sulfadiazine in Sprague Dawley rat models in improving healing process of SSIs. Methods: The study used a post-test only control group design to evaluate wound treatments on infected wound in rats. Thirty rats were divided into three groups: negative control (0.9% NaCl), positive control (0.9% NaCl + gentamicin), and treatment (0.9% NaCl + silver sulfadiazine). Standard wounds were treated accordingly and on day 14, tissue samples were analyzed for fibroblasts, neutrophils, macrophages, collagen, and wound diameter. Data were analyzed using One-Way ANOVA or Kruskal-Wallis for significant differences (p < 0.05). Results: Study showed treatment group had significantly higher fibroblast (p = 0.04), neutrophil (p = 0.00), and macrophage counts (p = 0.00), as well as collagen levels (p = 0.00), compared to both positive and negative control group. Wound size in treatment group was also significantly smaller. Conclusion: Silver sulfadiazine significant reduced fibroblast, neutrophil, macrophage, and collagen counts, as well as wound size.]]>
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