<![CDATA[Leprosy remains a public health problem requiring continuous preventive efforts. Rifampicin chemoprophylaxis is one strategy to reduce the risk of leprosy transmission among at-risk individuals. However, its effectiveness may depend on community behavior after rifampicin consumption. This study aimed to analyze the influence of knowledge, culture, family support, and access to health services on the behavior of indigenous communities after consuming rifampicin in Wamanabaru Village, within the working area of Lolong Guba Primary Health Center. This quantitative study used a cross-sectional design involving 264 respondents selected from a population of 774 individuals. Data were collected using validated and reliable questionnaires and analyzed using univariate, bivariate, and multivariate analyses with multiple linear regression. The results showed that knowledge (p=0.326), culture (p=0.649), family support (p=0.956), and access to health services (p=0.629) did not have significant partial effects on post-rifampicin consumption behavior. Simultaneously, the four variables also did not significantly influence behavior (F=0.425; p=0.790). Knowledge had the highest standardized beta coefficient (β=0.062), although it was not statistically significant. In conclusion, knowledge, culture, family support, and access to health services were not significant determinants of indigenous communities’ behavior after rifampicin consumption in leprosy chemoprophylaxis activities.]]>
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