This study aims to determine the effectiveness of the extract of Acalypha indica and plant Imperata cylindrica on glucose levels of mice (Mus musculus L) hyperglycemia. This study used 40 male ICR strain male mice which were divided into 8 treatment groups, namely normal mice group, hyperglycemia mice group, and mice group by giving methanol extract Acalypha indica and Imperata cylindrical plants at each dose of 150 and 250 mg / Kg bb. The results showed that the extract of the leaves of Acalypha indica and Imperata cylindrica plants showed a decrease in blood glucose levels of mice by 47-49%. The conclusion of this research is the effectiveness of the methanol extract of Acalypha indica and the Imperata cylindrical plant influences the decrease in blood glucose levels in hyperglycemia mice.
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