SMEs in Ambon City face sustainability challenges amid environmental pressures and limited stakeholder collaboration. This study examines the influence of social mission, social innovation, social networks (as moderator), and stakeholder engagement on business sustainability. Employing a quantitative causal design with SEM-PLS analysis via SmartPLS 3.0, the research targeted 627 registered SMEs, selecting 153 respondents via simple random sampling (Slovin formula, e=0.07). Data were collected through online Likert-scale questionnaires (5-point) and analyzed for validity, reliability, and hypothesis testing. Results reveal significant positive effects of social mission (β=0.190, p=0.020), social innovation (β=0.186, p=0.014), and stakeholder engagement (β=0.545, p<0.001) on business sustainability (R²=0.570), with social networks positively moderating social mission (β=0.285, p=0.005) but moderating social innovation (β=-0.195, p=0.012). Findings underscore strategic social entrepreneurship integration for SME resilience.
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