Toxic relationships are increasingly prevalent among university students' romantic partnerships, marked by emotional manipulation, control, and poor communication. This study aims to examine the influence of emotion regulation and self-esteem on toxic relationships, both partially and simultaneously. A quantitative method was applied through a survey of 275 active students from various faculties at Universitas Muhammadiyah Surakarta. Data were collected using validated and reliable Likert-scale instruments. Multiple linear regression analysis and classical assumption tests were employed. The findings revealed that both emotion regulation and self-esteem significantly influenced toxic relationships simultaneously, with emotion regulation being the dominant contributor. Students with higher emotion regulation and self-esteem levels showed lower tendencies to engage in destructive romantic interactions. These results imply the importance of enhancing emotional regulation skills and fostering self-esteem as preventive strategies to support healthy interpersonal relationships among university students
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