Indonesian Journal of Pharmaceutical Education
Vol 6, No 2 (2026): May–August 2026

The Use of Antihypertensive Drugs in Pre-Dialysis Chronic Kidney Disease Patients

Budi Suprapti (Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia. Department of Pharmacy, Universitas Airlangga Hospital, Surabaya, Indonesia.)
Mochammad Thaha (Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya, Indonesia)
Wenny Putri Nilamsari (Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia)
Ihsan Muhyidin (Bachelor of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia)
Vini Siane Tanaem (Magister of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia)
Euphrasiane Griseldis Beting (Magister of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia)



Article Info

Publish Date
30 Jun 2026

Abstract

In chronic kidney disease (CKD), hypertension plays a central role, acting as both a risk factor and a complication that contributes to disease progression. Effective control of blood pressure through antihypertensive therapy is essential for preserving kidney function and preventing clinical decline. Therefore, this study aimed to evaluate antihypertensive treatment and blood pressure target achievement in pre-dialysis CKD patients, with blood pressure targets defined as 130/80 mmHg and 140/80 mmHg in elderly patients. This study was a prospective observational study with a retrospective review of medical records over a 3-month period, and the data were subsequently analyzed using descriptive methods. Participants were pre-dialysis CKD patients aged 18 or older receiving antihypertensive therapy with complete blood pressure records. Among the 90 eligible patients, the most commonly used antihypertensive classes were angiotensin receptor blockers, particularly candesartan, and calcium channel blockers, specifically nifedipine, either as monotherapy or combined with two to five other antihypertensive drugs. Over three months, only an average of 23.3% of patients achieved blood pressure targets, and only 8.9% maintained that continuously. Therefore, a more effective blood pressure management strategy is needed to achieve the desired target blood pressure.

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Journal Info

Abbrev

ijpe

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

Description

ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open ...