Introduction: Chronic kidney disease (CKD) is one of the leading causes of death in the world that affects metabolic function. Hemodialysis (HD), as a commonly used kidney replacement therapy, often causes anxiety in patients due to the adaptation process to the hemodialysis routine. This study aims to determine the relationship between anxiety levels and blood pressure in CKD patients undergoing HD at Panembahan Senopati Hospital. Methods: This study aims to determine the relationship between anxiety levels and blood pressure in CKD patients undergoing HD at Panembahan Senopati Hospital Results: The results showed that the majority of respondents did not experience anxiety (55%), with normal blood pressure in 90% of respondents. The Pearson correlation test showed a moderate relationship between anxiety levels and blood pressure (r = 0.454, p = 0.003), and was positive, which means that the higher the anxiety, the higher the blood pressure. Conclusion: Further researchers are advised to conduct more in-depth interviews to explore anxiety symptoms, psychological approaches to managing mild anxiety, and further studies related to blood pressure fluctuations during hemodialysis
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