<![CDATA[Cervical cancer remains a major health burden among women, particularly in developing countries. Visual Inspection with Acetic Acid (VIA) is an economical, simple, and feasible early screening method for primary healthcare facilities. However, screening participation among women of reproductive age remains low, partly due to limited knowledge about cervical cancer and the importance of early detection. This study aimed to examine the relationship between knowledge and VIA screening uptake among women of reproductive age. A quantitative analytical observational study with a cross-sectional design was conducted at Morodadi Primary Health Center, Morotai Island Regency, from February to April 2026. Sixty women of reproductive age were selected using purposive sampling. Data were collected using a validated and reliable structured questionnaire and analyzed using univariate statistics and the Chi-square test at α = 0.05. High knowledge was found in 40.0% of respondents, moderate knowledge in 35.0%, and low knowledge in 25.0%. Overall, 60.0% had undergone VIA screening, while 40.0% had not. Chi-square analysis showed a significant relationship between knowledge and VIA screening uptake (p = 0.002). Higher knowledge was significantly associated with VIA screening uptake. Health promotion and reproductive health education should be strengthened to increase screening participation.]]>
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