Background: Quality health services are the result of cooperation between patients and health care providers in a supportive environment. Nurses as professionals are responsible for providing high-quality nursing care for better patient outcomes. The Human Resources (HR) department plays a crucial role in managing the workforce and ensuring that hospitals have qualified and competent staff of healthcare professionals. The purpose of this study is to find out the factors that affect nurses' job satisfaction. Subjects and Method: The cross-sectional study was conducted at the Sukoharjo Regency Hospital from June to July 2024. A total sample of 200 inpatient nurses was selected by simple random sampling. The dependent variable is job satisfaction. The independent variables were salary perception, work environment, autonomy, supervision, relationships between colleagues, work rewards, and work attitudes. Data collection was carried out by questionnaire. Data were analyzed using path analysis. Results: The results of the pathway analysis that has been carried out in this study stated that the job satisfaction of inpatient nurses at Sukoharjo Hospital was directly influenced by supervision (b=0.14; CI 95%= 0.01 to 0.26; p= 0.040), salary perception (b= 0.23; CI 95%= 0.10 to 0.36; p <0.001), autonomy (b = 0.18; CI 95%= 0.06 to 0.31; p= 0.005), work environment (b= 0.18; CI 95%= 0.05 to 0.31; p= 0.006). Job satisfaction through salary perception is indirectly influenced by income and work rewards in the work environment. Conclusion: The job satisfaction of inpatient nurses at Sukoharjo Hospital is directly influenced by supervision, salary perception, autonomy, and work environment. Job satisfaction through salary perception is indirectly influenced by income, work rewards in the work environment.
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