. Medication adherence is a key determinant of successful tuberculosis (TB) treatment. Poor adherence to anti-tuberculosis therapy increases the risk of treatment failure, disease progression, and drug-resistant tuberculosis. This study examined medication adherence assessed using the Morisky Medication Adherence Scale-8 (MMAS-8) and its association with treatment outcomes among patients with TB. A cross-sectional study was conducted among 40 tuberculosis patients receiving treatment at Wayaloar Primary Health Center, South Halmahera, North Maluku, Indonesia, from March to June 2026. Sociodemographic characteristics, behavioral factors, medication adherence, and treatment outcomes were obtained from structured questionnaires and medical records. Medication adherence was assessed using the MMAS-8 and categorized as adherent or non-adherent. Descriptive statistics and Fisher’s exact test were performed using IBM SPSS Statistics version 25, with statistical significance set at p< 0.05. Overall, 87.5% of participants were adherent to anti-tuberculosis medication, and 92.5% achieved successful treatment outcomes. Educational level was significantly associated with medication adherence (p = 0.009), as was treatment outcome (p = 0.036). No significant associations were observed for age, sex, employment status, smoking history, or alcohol consumption. Good medication adherence was associated with favorable treatment outcomes. Strengthening adherence-support interventions and patient education may improve tuberculosis treatment success.
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