This study addresses the gap in teacher education frameworks that integrate Education 5.0 principles with empirically validated metacognitive development. The purpose was to develop and validate a seven-stage human-centric instructional framework, the setting goals, task analysis, universal design, digital learning, integrated knowledge, evaluation, standards-based assessment (STUDIES) model, grounded in constructivism, self-determination theory, and digital humanism, and to evaluate its effectiveness across three sequential phases with pre-service teachers. Three published phases employed one-group pretest–posttest designs. Phase I (N=24, English education) achieved efficiency ratios E1/E2 of 80.56/80.68 (t(23)=26.17, p
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