<![CDATA[This study aims to integrate the values of religious moderation into clinical interventions to enhance the Quality of Life (QoL) of children with autism through a meta-analytic approach covering studies published between 2020 and 2025. The analysis included 21 national and international studies examining the relationship between moderate spirituality, psychological well-being, and the effectiveness of behavioral therapies in autistic children. Findings revealed that conventional interventions such as ABA and PRT demonstrated a moderate effect size (0.52), while the integration of moderation values al-wasatiyyah (balance), al-ta‘ayush (coexistence), and al-ihsan (benevolence) increased the effect size to 0.73 with high-quality evidence (GRADE). The Moderate Religious Clinical Integration Model (MRCIM) developed in this research presents a bio-psycho-socio-spiritual framework that bridges scientific principles with Islamic moderation in clinical practice. This model effectively enhances emotional regulation, social acceptance, and spiritual well-being among children with autism. The study provides both conceptual and practical implications for psychologists, educators, and families in designing humanistic and adaptive clinical interventions grounded in the principles of religious moderation as a holistic healing paradigm in contemporary contexts]]>
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