<![CDATA[Introduction Nasopharyngeal carcinoma is a malignant tumor that originates from the epithelial cells of the nasopharyngeal mucosa or gland and is a malignant tumor of the head and neck area. Immunohistochemistry Protein 16 is a tumor suppressor gene (TSG), which is a cyclin-dependent kinase (CDK) inhibitor that regulates tumor cells through the G1 phase of the often inactive cell cycle in cancer. Research on the relationship of p16 expression to nasopharyngeal carcinoma has not been done much. Method This study used 46 slide/block samples of paraffin in Nasopharyngeal carcinoma cases that had been histopathologically diagnosed at the Anatomical Pathology Unit of H. Adam Malik Hospital Medan from January 2022 to May 2024. All clinicopathology data is taken from medical records/pathology archives. p16 expression is assessed in the nucleus and or cytoplasm of tumor cells. The assessment of p16 expression was carried out semi-quantitatively based on the multiplication of area and intensity in the expressed tumor cells. Statistical analysis was carried out using the Eta test. Result Among the 46 nasopharyngeal carcinoma samples, 21 samples were found to have positive expressions with strong positive values in the NKSCC subtype as many as 14 samples (30.4%) and weak positive values in the NKSCC subtype as many as 7 samples (15.2%). Meanwhile, the results of immunohistochemical staining p16 were most negatively expressed, namely in the NKSCC subtype as many as 23 samples (50.0%) and in the KSCC subtype as many as 2 samples (4.3%). This variable Eta test was carried out and a p-value of 0.195 was obtained. Conclusion There was no relationship of p16 expression to the nasopharyngeal carcinoma subtype.]]>
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