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All Journal Jurnal Kedokteran Syiah Kuala Majalah Patologi Indonesia Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Kedokteran STM (Sains dan Teknologi Medik) Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Mariedina, Causa Trisna
Department Of Pathology Anatomy, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Analisis Ekspresi Estrogen Receptor (ER) dan Progesteron Receptor (PR) pada Tipe dan Grading Histopatologik Karsinoma Endometrium Causa Trisna Mariedina; Soekimin Soekimin; Delyuzar Delyuzar
Majalah Patologi Indonesia Vol 26 No 3 (2017): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.024 KB)

Abstract

Latar belakangKarsinoma endometrium merupakan tumor ganas organ reproduksi wanita yang paling sering dijumpai, dengan insidennya yang terus meningkat, terutama pada wanita-wanita postmenopause di negara-negara berkembang. Perkembangan karsinoma endometrium sangat erat kaitannya dengan hormon estrogen. Paparan estrogen dalam waktu panjang tanpa dihalangi efek progesteron dapat meningkatkan risiko terjadinya karsinoma endometrium. Epitel glandular endometrium merupakan lokasi keganasan yang sangat responsif terhadap hormon, dalam hal ini akan diekspresikan melalui estrogen receptor (ER) dan progesterone receptor (PR). ER dan PR yang akan berikatan dengan hormon estrogen dan progesteron pada jaringan endometrium relatif akan berkurang jumlahnya pada karsinoma endometrium, dan hilangnya reseptor-reseptor tersebut merupakan bagian dari karsinogenesis endometrium. Beberapa parameter histopatologi, seperti tipe dan grading histopatologi akan mempengaruhi ekspresi reseptor-reseptor tersebut. Tujuan penelitian ini untuk menganalisis ekspresi ER dan PR pada tipe dan grading histopatologik karsinoma endometrium.MetodePenelitian ini merupakan penelitian deskriptif analitik dengan pendekatan secara cross sectional. Sampel penelitian adalah blok parafin jaringan endometrium yang didiagnosa secara histopatologi sebagai karsinoma endometrium. Sampel dipulas dengan imunohistokimia ER dan PR. Uji statistik dilakukan untuk menganalisis ekspresi ER dan PR pada tipe dan grading histopatologik.HasilEkspresi ER pada tipe endometrioid (78,8%) dan kasus low grade (90,2%) sedang ekspresi PR pada tipe endometrioid (82,7%) dan kasus low grade (90,2%).KesimpulanEkspresi ER dan PR dapat digunakan untuk membedakan antara tipe dan grading histopatologik low grade pada karsinoma endometrium.
ADENOKARSINOMA KOLON PADA BAYI BERUSIA 14 HARI Fitri Dewi Ismida; Causa Trisna Mariedina; Safarianti safarianti
Jurnal Kedokteran Syiah Kuala Vol 21, No 1 (2021): Volume 21 Nomor 1 April 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i1.20185

Abstract

Adenokarsinoma kolon merupakan salah satu jenis kanker yang paling banyak dijumpai, sekitar 15% dari seluruh kanker yang mematikan. Umumnya kanker ini terjadi pada usia dewasa dan jarang dijumpai pada anak-anak. Dilaporkan sebuah kasus adenokarsinoma kolon pada seorang bayi laki-laki berusia 14 hari yang disangkakan sebagai Hirschprung’s disease. Dilakukan pemeriksaan secara histopatologi terhadap massa tumor dari kolon. Setelah jaringan difiksasi dengan formalin 10%, dilakukan  pemrosesan standar menggunakan blok parafin dengan pewarnaan Hematoxylin Eosin. Jaringan kemudian dievaluasi di bawah mikroskop cahaya binokuler. Gambaran histopatologi jaringan dari kolon, tampak lapisan mukosa hingga serosa. Lapisan mukosa terdiri dari struktur kelenjar yang mengalami disorganisasi. Kelenjar dengan pelapis epitel yang proliferatif, inti bulat oval membesar, kromatin kasar, sitoplasma eosinofilik. Stroma terdiri dari jaringan fibrous yang diinfiltrasi oleh sel-sel tumor dan sebukan sel-sel radang polimorfonuklear yang masif. Sel-sel tumor tampak telah menyusup di antara lapisan muskularis. Pembuluh darah proliferatif, sebagian dilatasi dan kongesti. Hasil pemeriksaan histopatologi menunjukkan gambaran yang sesuai dengan karakteristik adenokarsinoma kolon Kata kunci. Adenokarsinoma kolon, adenokarsinoma, kolon
Characteristics of Lung Cancer Patients in Haji Adam Malik General Hospital Medan in 2016-2018 Sivabalan Logawathi, Satthiyabalan; Causa Trisna Mariedina
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 1 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (734.011 KB) | DOI: 10.32734/jetromi.v2i1.3280

Abstract

Lung cancer is a malignant disease in the lung where abnormalities caused by collection of genetic changes in the epithelial cells of the airway, which lead to cell proliferation that cannot be controlled. This study was conducted to determine the characteristics of lung cancer patients in Haji Adam Malik General Hospital Medan in 2016-2018. This research is a descriptive study with a case series approach. The study population was 311 lung cancer patients using Total Sampling method. The tendency of inpatient lung cancer patients visiting H. Adam Malik General Hospital Medan in 2016-2018 has decreased. The highest proportion of patients with lung cancer based on sociodemography obtained 65-69 years old age group, men with 3: 1 sex ratio, work of farmers, living outside the city of Medan, the main complaint was more than one complaint, had a history of smoking, no pleural effusion occurred, the type of adenocarcinoma histology and the method of taking a cytological fluid specimen. There was a statistically significant relationship between age with sex, sex with occupation, sex with smoking history, occupation with primary complaints, occupation with smoking history, and histology type by specimen collection and there rest have no statistically significant difference.
The Level of Handwashing Knowledge and Behavior of Yos Sudarso High School Medan Students' During The COVID-19 Pandemic Elvira, Cindy; Mariedina, Causa Trisna
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 1 (2021): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (643.787 KB) | DOI: 10.32734/jetromi.v3i1.5554

Abstract

Background: The COVID-19 (Coronavirus Disease 2019) outbreak which was first detected in Wuhan, China, in December 2019, has spread rapidly. One way of preventing and controlling infection in the community is by washing hands thoroughly and regularly. The purpose of this study was to determine the level of handwashing knowledge and behavior of Yos Sudarso High School Medan students’ during the COVID-19 pandemic. Method: The design used was one group pretest-posttest design. The type of data is primary data obtained through online questionnaires using a total sampling technique. Results: Of the 76 respondents, the level of knowledge on handwashing was dominated by the low category, namely 65 people (85.5%) and the good category of handwashing behavior, namely 59 people (77.6%). After being given information, the level of the good knowledge was 35 people (46.1%) and the good behavior was 66 people (86.8%). Students have a low knowledge about handwashing but have a good handwashing intensity behavior during the COVID-19 pandemic. Conclusion: Given information, there is an increase on the level of handwashing knowledge and behavior of Yos Sudarso High School Medan students’ during the COVID-19 pandemic.
High Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Correlates with High Grade of Clear Cell Renal Cell Carcinoma Rezeki, Dewi Sri; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Alferraly, T. Ibnu; Lukito, Joko S.; Betty, Betty
Majalah Patologi Indonesia Vol. 33 No. 2 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.581

Abstract

Background Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype in renal cell tumors (RCT). This is a very aggressive cancer, often diagnosed at advanced stage leading to increase morbidity and mortality rates. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX-4) expression plays role in the regulation of several cancer types. The expression of NOX-4 is associated with a poorer degree of differentiation and a shorter survival in RCT. Therefore, NOX-4 expression is predictor of prognosis and potential therapeutic target. Research on the correlation of NOX-4 expression in RCTs is still very limited, while Correlation of NOX-4 expression in ccRCC does not exist yet.   Objective To assess the relationship between NOX-4 expression and ISUP grading in ccRCC.   Method In this study, 30 slide samples and ccRCC paraffin blocks were diagnosed histopathologically at Department of Anatomic Pathology of H. Adam Malik General Hospital from January 2012 to April 2022. All clinicopathological data were taken from medical records/pathology archives. The expression of NOX-4 immunohistochemical was assessed in nucleus and cytoplasm of tumor cells. The assessment was carried out semiquantitatively based on intensity and percentage of expressed tumor cells. The relationship between NOX-4 expression and ISUP grading was assessed using Fisher's exact test.   Results Of the 30 ccRCC samples, high grade ccRCC was found in 21 cases (70%) and strong expression of NOX-4 in cytoplasm and nucleus in 20 cases (66.7%). Strong expression of NOX-4 in high grade ccRCC was found in 17 cases (81.0%). A significant relationship was observed between NOX-4 expression and ISUP grading on ccRCC with a p-value of 0.030 (p<0.05) using Fisher's exact test.   Conclusion There is a significant relationship between NOX-4 expression and ISUP grading in ccRCC. Therefore, NOX-4 expression can be used for the prognosis of ccRCC and therapy development.
Correlation between Reactive Stromal Expression and Histochemical Trichrome Masson Staining with Histopathological Grading in Prostate Adenocarcinoma at Adam Malik Haji Center General Hospital Medan Basrul, Mohd. Yuwanda; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Lubis, M. Nadjib Dahlan; Intan, T. Kemala; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.584

Abstract

Background Adenocarcinoma of the prostate is an invasive carcinoma, composed of neoplastic prostatic epithelial cells with differentiation and secretion arranged in various histomorphological patterns.Quantitative analysis of the elements that make up the stroma in casesprostate adenocarcinomahas been linked to prognostic factors and the Gleason score, which correlates with progression and metastasis, and may contribute to new prognostic feature approaches.   Method Descriptive analytic study with 33 paraffin block samples diagnosed as prostate adenocarcinoma at Haji Adam Malik General Hospital Medan.Assessment is done forsee the relationship between reactive stromal expression using Trichrome Masson and histopathological grading gleason score then determine the scoring score for the stroma around the prostate gland adenocarcinoma lesion stained blue with trichrome masson, a positive score of one (+): if 0-15% stroma is stained blue, positive two (++): if >15%-<50% stroma is stained and triple positive (+++): if >50% stroma is stained blue. The histopathological grading was categorized into grade I (well differentiated: Gleason score ≤6), grade II (moderately differentiated: Gleason score 7 (3+4)), and grade III (poorly differentiated: Gleason score 7 (4+3) and 8 -10).   Results: Reactive stromal expression the most found was positive three (+++) (69.7%) and the most common histopathological grading was grade III (69.7%). There was a significant correlation between reactive stromal expression and histopathological grading in prostate adenocarcinoma (p-value=0.044), namely the worse the cell differentiation, the higher the positive score of reactive stromal expression.   Conclusion Assessment of reactive stromal expression associated with histopathological grading can be used as an indication of prognosis in patients with prostate adenocarcinoma.
HUBUNGAN EKSPRESI PD-L1 DAN DENSITAS TILS PADA SUBTIPE KARSINOMA OVARIUM: CORRELATION OF PD-L1 EXPRESSION AND TILS DENSITY IN OVARIAN CARCINOMA SUBTYPES Kadri, Sayed Muhammad; Mariedina, Causa Trisna; Betty; Laksmi, Lidya Imelda; Lubis, Nadjib Dahlan
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 8 No. 2 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v8i2.926

Abstract

Background: PD-L1 and tumor-infiltrating lymphocytes (TILs) are essential components of the tumor microenvironment, playing key roles in modulating immune responses against ovarian carcinoma. However, the relationship between these two markers remains underexplored, especially across different histopathological subtypesMethods: A cross-sectional analytical study was conducted on 40 ovarian carcinoma cases using immunohistochemistry. PD-L1 expression and TIL density were evaluated in both intratumoral and stromal compartments. The Somers’ D test was used to analyze the correlation between variables.Results: Most patients were aged 40–50 years and presented with stage I disease. The predominant histopathological subtype was serous carcinoma. Intratumoral and stromal TIL densities were mostly low (77.5% and 72.5%, respectively). Positive intratumoral PD-L1 expression was observed in only 5% of cases, while no stromal PD-L1 expression was detected. No statistically significant correlation was found between PD-L1 expression and TIL density, either overall or by subtype.Conclusion: No significant correlation was observed between PD-L1 expression and TIL density in ovarian carcinoma subtypes. The variability in their expression suggests immune microenvironment heterogeneity, supporting the need for separate evaluation of these biomarkers and individualized approaches to immunotherapy. AbstrakLatar Belakang: PD-L1 dan TILs merupakan komponen utama dalam mikrolingkungan tumor yang berperan penting dalam regulasi respons imun terhadap karsinoma ovarium. Hubungan antara keduanya masih jarang dikaji, khususnya pada berbagai subtipe histopatologi.Tujuan: Menilai hubungan antara ekspresi PD-L1 dan densitas TILs pada beberapa subtipe karsinoma ovarium.Metode: Penelitian cross-sectional analitik pada 40 kasus karsinoma ovarium menggunakan pewarnaan imunohistokimia. Ekspresi PD-L1 dan densitas TILs dianalisis pada area intratumoral dan stromal. Uji korelasi Somers’ D digunakan untuk menilai hubungan antar variabel.Hasil: Mayoritas pasien berusia 40–50 tahun dan berada pada stadium klinis I, dengan subtipe terbanyak adalah serous carcinoma. Densitas TILs intratumoral dan stromal sebagian besar tergolong rendah (77,5% dan 72,5%). Ekspresi PD-L1 intratumoral positif ditemukan pada 5% kasus, sedangkan ekspresi PD-L1 stromal tidak ditemukan. Tidak terdapat hubungan yang bermakna antara ekspresi PD-L1 dan densitas TILs, baik secara keseluruhan maupun berdasarkan subtipe.Kesimpulan:Tidak ditemukan korelasi signifikan antara ekspresi PD-L1 dan densitas TILs pada subtipe karsinoma ovarium. Variasi pola ekspresi antar subtipe mencerminkan heterogenitas imun tumor, sehingga diperlukan evaluasi terpisah PD-L1 dan TILs sebagai biomarker serta pendekatan individualisasi dalam terapi imun.
PEMERIKSAAN IMUNOHISTOKIMIA CLAUDIN-4 PADA PREPARAT CELL BLOCK CAIRAN EFUSI PLEURA BERDASARKAN KATEGORI DIAGNOSTIK THE INTERNATIONAL SYSTEM FOR REPORTING SEROUS FLUID CYTOPATHOLOGY: IMMUNOHISTOCHEMICAL EXAMINATION OF CLAUDIN-4 ON CELL BLOCK PREPARATIONS OF PLEURAL EFFUSION FLUIDS BASED ON DIAGNOSTIC CATEGORIES OF THE INTERNATIONAL SYSTEM FOR REPORTING SEROUS FLUID CYTOPATHOLOGY Kuncara, Dede Bisma; Mariedina, Causa Trisna; Betty; Lukito, Joko S; Chrestella, Jessy
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 24 No. 2 (2025): Juli 2025
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v24i2.746

Abstract

Efusi pleura mencerminkan kondisi patologis seperti gangguan paru, pleura, sistemik, hingga keganasan. Pemeriksaan sitologi dan imunohistokimia (IHK) cairan efusi pleura bertujuan untuk menilai keterlibatan pleura terhadap metastasis dan meningkatkan ketepatan diagnosis serta penilaian prognostik. Claudin-4, protein transmembran, diketahui terekspresi secara konsisten pada adenokarsinoma metastatik. Penelitian ini bertujuan mengetahui ekspresi IHK Claudin-4 pada sediaan cell block cairan efusi pleura berdasarkan The International System for Reporting Serous Fluid Cytopathology. Penelitian ini merupakan studi deskriptif analitik dengan pendekatan potong lintang terhadap 49 sampel cairan efusi pleura yang diproses menjadi cell block, kemudian dilakukan pewarnaan Hematoksilin-Eosin dan IHK Claudin-4 di RS Pendidikan Prof. dr. Chairuddin Panusunan Lubis USU. Hasil menunjukkan kelompok usia terbanyak 41–50 tahun (32,65%), laki-laki lebih banyak (55,10%), cairan transudat (57,14%), dan volume efusi 11–20 mL (30,61%). Diagnosis sitologi terbanyak adalah kategori NFM (85,72%) dan MAL (14,28%). Ekspresi Claudin-4 positif ditemukan pada seluruh sampel kategori MAL (7/7) dan negatif pada kategori NFM (42/42). Simpulan: Ekspresi Claudin-4 positif pada semua kasus MAL dan negatif pada NFM, menunjukkan potensi Claudin-4 sebagai penanda diagnostik untuk efusi pleura maligna.
Comparison of Examination Results of Cytocentrifuge Cytology and Cell Block Methods on Pleural Fluid Confirmed with Calretinin Immunohistochemistry as Mesothelial Cell Marker Fitri Desimilani, Fitri Desimilani; Mariedina, Causa Trisna; Betty, Betty; Soekimin, Soekimin; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.627

Abstract

Background Pleural effusion is an abnormal accumulation of fluid in the pleural cavity, which occurs as a result of disturbance in the balance between production and reabsorption. Cytologycal examination is important as diagnosis, determining the stage, guiding further treatment for malignancy. Effusion fluid is often processed using cytocentrifuge cytology or cell block methods which have their advantages and disadvantages. Calretinin as mesothelial cell marker valuable for establishing a more definitive cytopatholgical diagnosis. Methods Analytic observational study with a cross-sectional approach of 49 samples cytologically diagnosed pleural fluid specimens at private hospital in Medan. Examination method cytocentrifuge cytology and cell block followed calretinin immunohistochemistry. Data analysis was tested with Chi-square test. Results The result of pleural effusion examination were confirmed by calretinin immunohistochemistry, which showed positive mesothelial cell in 45 cases (91,8%), while those who did not show or negative mesothelial cell were 4 cases (8,2%). Conclusion There was a significant different between the result of the cytocentrifuge cytology and cell block methods with a p-value < 0,001.
Co-Authors Alferraly, T. Ibnu Basrul, Mohd. Yuwanda Betty betty betty Chrestella, Jessy Delyuzar, Delyuzar Elvira, Cindy Fitri Desimilani, Fitri Desimilani Fitri Dewi Ismida Intan, T. Kemala Kadri, Sayed Muhammad Kuncara, Dede Bisma Laksmi, Lidya Imelda Lubis, M. Nadjib Dahlan Lukito, Joko S Lukito, Joko S. Nadjib Dahlan Lubis Rezeki, Dewi Sri Safarianti Safarianti Sivabalan Logawathi, Satthiyabalan Soekimin Soekimin Soekimin Soekimin, Soekimin