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Lidya Imelda Laksmi
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Health Professions Public Health

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Ekspresi AgNOR dan Ekspresi Ki-67 pada Grading Adenokarsinoma Prostat Roza Rita; Delyuzar; Lidya Imelda Laksmi
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.782 KB) | DOI: 10.55816/mpi.v29i3.446

Abstract

BackgroundProstate cancer is the second most common cancer and fifth most common cancer cause of death in males. Tissue biopsy is a goldstandard examination to diagnose prostate cancer. One of the hallmarks of cancer is increased activity of cell proliferation. Thisactivity can be detected with Ki-67 and AgNOR (Argyrophilic nucleolar organizing region). The aim of this study is to analyzedcorrelation between AgNOR and Ki-67 expression in grading of prostated adenocarcinoma.MethodsThis analytic cross-sectional study was held in Laboratory of Anatomical Pathology of Medical Faculty of USU/ RSUP H. AdamMalik Medan. Thirty paraffin blocks diagnosed with prostate adenocarcinoma were stained with H&E and p63 immunohistochemistrythen evaluated based on Gleason’s histopathological grading and stained with Agnor and Ki 67.ResultsAgNOR expression yang diperoleh pada grading adenokarsinoma prostat group 1, 2, 3, 4, dan 5 berturut-turut adalah 43; 32,40(±14,54); 64,29 (±28,2); 59,5 (±28,32); 69,22 (±29,26). Ekspresi Ki-67 pada setiap grading adenokarsinoma prostat group 1, 2, 3, 4,dan 5 secara berurutan adalah 43; 32,4 (±14,53); 64,29 (±28,2), 59,5 (±28,31); 69,22 (±29,26). Statistical analyses showed thatthere was no significantly correlation between grading of prostate adenocarcinoma and AgNOR expression (p=0.065), and Ki-67expression (p=0.18). Nevertheless, a significantly correlation between KI-67 expression and grading of prostate adenocarcinomawas found (p=0.34).ConclusionKi-67 could be used as prognostic indicator for prostate adenocarcinoma.
Ekspresi AgNOR dan Ekspresi Ki-67 pada Grading Adenokarsinoma Prostat Roza Rita; Delyuzar; Lidya Imelda Laksmi
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.446

Abstract

BackgroundProstate cancer is the second most common cancer and fifth most common cancer cause of death in males. Tissue biopsy is a goldstandard examination to diagnose prostate cancer. One of the hallmarks of cancer is increased activity of cell proliferation. Thisactivity can be detected with Ki-67 and AgNOR (Argyrophilic nucleolar organizing region). The aim of this study is to analyzedcorrelation between AgNOR and Ki-67 expression in grading of prostated adenocarcinoma.MethodsThis analytic cross-sectional study was held in Laboratory of Anatomical Pathology of Medical Faculty of USU/ RSUP H. AdamMalik Medan. Thirty paraffin blocks diagnosed with prostate adenocarcinoma were stained with H&E and p63 immunohistochemistrythen evaluated based on Gleason’s histopathological grading and stained with Agnor and Ki 67.ResultsAgNOR expression yang diperoleh pada grading adenokarsinoma prostat group 1, 2, 3, 4, dan 5 berturut-turut adalah 43; 32,40(±14,54); 64,29 (±28,2); 59,5 (±28,32); 69,22 (±29,26). Ekspresi Ki-67 pada setiap grading adenokarsinoma prostat group 1, 2, 3, 4,dan 5 secara berurutan adalah 43; 32,4 (±14,53); 64,29 (±28,2), 59,5 (±28,31); 69,22 (±29,26). Statistical analyses showed thatthere was no significantly correlation between grading of prostate adenocarcinoma and AgNOR expression (p=0.065), and Ki-67expression (p=0.18). Nevertheless, a significantly correlation between KI-67 expression and grading of prostate adenocarcinomawas found (p=0.34).ConclusionKi-67 could be used as prognostic indicator for prostate adenocarcinoma.
The Association between Matrix Metalloproteinase-9 (MMP-9) Immunohistochemical Expression and Gleason Grading System International Society of Urological Pathology (ISUP) in Prostate Adenocarcinoma Sefparina Harahap; Jessy Chrestella; Lidya Imelda Laksmi; T. Ibnu Alferraly; Betty Betty
Majalah Patologi Indonesia Vol. 35 No. 1, Januari 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.635

Abstract

Background Prostate cancer is the fourth ranked malignancy and the eighth leading mortality worldwide. The Gleason grading system is used to evaluate the tumor grade. The highest the score, the worst and the most aggressive the nature of the tumor, which associated with invasive behaviour. In prostate carcinoma, Matrix Metalloproteinase-9 (MMP-9) is involved in all stages of cancer cell progression include proliferation, angiogenesis, apoptosis, epithelial-mesenchymal transition (EMT) and metastasis. MMP-9 degrade the surrounding tumor matrix and neural tissue during perineural invasion in prostate carcinoma which is a prerequisite for invasion and metastasis. The aim of this research is to evaluate the correlation of MMP-9 immunohistochemical expression with the Gleason Grading System International Society of Urological Pathology (ISUP) of prostate adenocarcinoma. Methods Cross sectional analytic study of 32 samples were diagnosed with prostate adenocarcinoma at H. Adam Malik General Hospital Medan. Staining was performed using a polyclonal antibody rabbit MMP-9 immunohistochemistry (Bioenzy) which would appear positive in the cytoplasm and in stroma of the tumor cell at a dilution of 1: 100 (overnight). MMP-9 expression was assessed semi quantitatively based on intensity and tumor cell distribution with four-tier expression categories. Data analysis was tested with the Kruskal-Wallis test. Results Most cases (56,25%) were strongly positive with MMP-9 and MMP-9 immunohistochemical expression has a significant relationship with Gleason Grading ISUP System of prostate adenocarcinoma (p:0.001). Conclusion There was a significant association between MMP-9 immunohistochemical expression and the Gleason Grading ISUP System of prostate adenocarcinoma. Keyword: Prostate adenocarcinoma, ISUP, Gleason grading, matrix metalloproteinase-9
Co-Authors betty betty Delyuzar, Delyuzar Jessy Chrestella Roza Rita Sefparina Harahap T. Ibnu Alferraly