Medication errors among children in household settings remain a leading cause of preventable harm, particularly in small island areas with limited access to healthcare professionals such as Kasu Island, Belakang Padang District, Batam City. This community service program aimed to improve the knowledge and skills of parents, integrated health post (posyandu) cadres, and early childhood teachers regarding safe medication use in children through an interprofessional approach involving pharmacists, physicians, nurses, and midwives. The activity was conducted on February 2, 2025, through field visits by an interprofessional team to posyandu cadres, using interactive lectures based on the DAGUSIBU principles, demonstrations of liquid dosage measurement, case simulations of fever and diarrhea in children, and interprofessionally facilitated focus group discussions. Evaluation employed a one-group pretest–posttest design involving 42 participants. The results showed a significant increase in the mean knowledge score from 50.4 ± 10.9 to 83.5 ± 7.8 (p<0.001; Wilcoxon test), with the greatest improvement in medicine disposal and prudent antibiotic use. The interprofessional approach effectively strengthened medication literacy in the island community and is recommended for replication in other hinterland areas with sustained mentoring through posyandu.
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