Background: People living with HIV may experience persistent physical symptoms, stigma, psychological distress, social disruption, and spiritual concerns despite advances in antiretroviral therapy. Quality of life is a multidimensional patient-reported outcome that complements viral suppression. Objective: To describe quality of life among people living with HIV recruited in Kendari City. Methods: A descriptive cross-sectional study included 58 participants recruited through closed community or peer-support networks using an anonymous online questionnaire. Quality of life was measured with the 31-item WHOQOL-HIV BREF and summarized using the study’s recorded overall categories: poor, moderate, and good. Demographic characteristics were summarized using frequencies and percentages. No inferential analysis was performed. Results: Poor quality of life was reported by 33 participants (56.9%), moderate quality of life by 14 (24.1%), and good quality of life by 11 (19.0%). Most participants were male (36/58; 62.1%), aged 20–29 years (42/58; 72.4%), and not married (47/58; 81.0%). Marital status was not reported for 6 participants (10.3%). Conclusion: Poor quality of life predominated in this sample. HIV nursing should integrate symptom assessment, mental-health screening, stigma-sensitive communication, adherence support, and social and spiritual care while avoiding assumptions based on sex or marital status. Domain-level WHOQOL-HIV BREF reanalysis is recommended to identify specific priorities.
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