<![CDATA[Paracetamol is an analgesic and antipyretic drug available in both generic and branded forms. This study is aimed to compare the paracetamol content of the two types of tablets using a validated UV-Vis spectrophotometry method. This experimental study employed six tablet samples, consisting of three of each generic products and branded products from different manufacturers, with each sample analysed three times (n = 3). The method validation included linearity testing, LOD, LOQ, accuracy, and precision, while the statistical analysis was conducted using Shapiro–Wilk, Levene, and Kruskal–Wallis tests. The results of the study indicated a correlation coefficient (R) of 0.999, an LOD of 1.618 mg/L, a LOQ of 5.395 mg/L, a % recovery of 103.314–106.542%, and a %RSD of less than 2%. The paracetamol content of all samples was within the range 91.523%–100.881%, thus meeting the requirements of the Indonesian Pharmacopoeia VI (90.0%–110.0%). The Kruskal–Wallis test indicated that there were significant differences in the concentrations of the six samples (p = 0.029). Therefore, the UV-Vis spectrophotometry method is valid for determining the paracetamol content and all samples meet the Pharmacopeia Indonesia requirements.]]>
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