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All Journal Pharmademica: Jurnal Kefarmasian dan Gizi
Ade Via Juliana
Program Studi Ilmu Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Indonesia
Chemistry Public Health

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Perbandingan Kadar Parasetamol antara Obat Generik dan Obat Merek Dagang yang Beredar di Pasaran dengan Metode Spektrofotometri UV-Vis Ade Via Juliana; Rahmi Hutabarat; Theodorus Rexa Handoyo
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 6 No 1 (2026): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v6i1.188

Abstract

Paracetamol is an analgesic and antipyretic drug available in both generic and branded forms. This study is aimed to compare the paracetamol content of the two types of tablets using a validated UV-Vis spectrophotometry method. This experimental study employed six tablet samples, consisting of three of each generic products and branded products from different manufacturers, with each sample analysed three times (n = 3). The method validation included linearity testing, LOD, LOQ, accuracy, and precision, while the statistical analysis was conducted using Shapiro–Wilk, Levene, and Kruskal–Wallis tests. The results of the study indicated a correlation coefficient (R) of 0.999, an LOD of 1.618 mg/L, a LOQ of 5.395 mg/L, a % recovery of 103.314–106.542%, and a %RSD of less than 2%. The paracetamol content of all samples was within the range 91.523%–100.881%, thus meeting the requirements of the Indonesian Pharmacopoeia VI (90.0%–110.0%). The Kruskal–Wallis test indicated that there were significant differences in the concentrations of the six samples (p = 0.029). Therefore, the UV-Vis spectrophotometry method is valid for determining the paracetamol content and all samples meet the Pharmacopeia Indonesia requirements.
Co-Authors Rahmi Hutabarat Theodorus Rexa Handoyo