<![CDATA[Matoa (Pometia pinnata) leaves contain flavonoids, saponins, and tannins with antioxidant, anti-inflammatory, antiseptic, and skin regenerative activities that promote burn wound healing. This study aimed to evaluate the effectiveness of Pometia pinnata leaf extract ointment in healing second-degree burns in mice (Mus musculus). The leaves were extracted by maceration using 70% ethanol. The extract was qualitatively screened for phytochemicals and formulated into ointments: F0 (ointment base), F1 (5% w/w), F2 (7.5% w/w), and F3 (10% w/w). Organoleptic properties, homogeneity, pH, spreadability, adhesiveness, and viscosity were evaluated. F0 was a white semi-solid ointment with the characteristic odor of the base, whereas F1–F3 were light- to dark-brown semi-solid ointments with the characteristic odor of the extract. All formulations were homogeneous. Viscosity ranged from 9,087±977 to 13,697±468 cPs, spreadability from 5.07±0.08 to 5.25±0.05 cm, adhesiveness from 9.33±0.44 to 13.24±0.84 s, and pH from 4.62±0.02 to 5.96±0.08. Significant differences were observed in viscosity (p<0.001), spreadability (p=0.015), adhesiveness (p<0.001), and pH (p<0.001). On day 14, wound healing reached 96% in F0 and 100% in F1–F3 and the positive control (p=0.406). The 10% w/w Pometia pinnata leaf extract ointment was the most effective formulation for accelerating second-degree burn wound healing. ABSTRAK Daun matoa (Pometia pinnata) mengandung flavonoid, saponin, dan tanin yang berperan dalam penyembuhan luka. Senyawa tersebut memiliki aktivitas antioksidan, antiinflamasi, antiseptik dan merangsang regenerasi sel kulit sehingga mempercepat penyembuhan luka bakar. Luka bakar derajat II ditandai kerusakan epidermis dan sebagian dermis disertai nyeri serta lepuh. Penelitian ini bertujuan menganalisis efektivitas salep ekstrak daun matoa terhadap penyembuhan luka bakar derajat II pada mencit (Mus musculus). Ekstraksi daun matoa dilakukan dengan maserasi menggunakan etanol 70%. Ekstrak diskrining fitokimia secara kualitatif dan diformulasikan menjadi salep F0 (basis), F1 (5% b/b), F2 (7,5% b/b), dan F3 (10% b/b). Evaluasi meliputi organoleptis, homogenitas, pH, daya sebar, daya lekat, dan viskositas. F0 berbentuk semi padat, berwarna putih, dan berbau khas basis, sedangkan F1–F3 berbentuk semi padat, berwarna cokelat muda hingga cokelat tua, dan berbau khas ekstrak. Seluruh formula homogen. Nilai viskositas 9.087±977–13.697±468 cPs, daya sebar 5,07±0,08–5,25±0,05 cm, daya lekat 9,33±0,44–13,24±0,84 detik, serta pH 4,62±0,02–5,96±0,08. Analisis statistik menunjukkan viskositas (p<0,001), daya sebar (p=0,015), daya lekat (p<0,001), dan pH (p<0,001) berbeda signifikan. Persentase kesembuhan hari ke-14 mencapai 96% pada F0 dan 100% pada F1, F2, F3, serta kontrol positif (p=0,406). Konsentrasi 10% b/b paling optimal mempercepat penyembuhan luka bakar.]]>
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