<![CDATA[Work-related fatigue is an occupational health problem that affects workers' productivity, safety, and well-being; however, evidence regarding the effectiveness of core exercise in reducing it remains scattered and has not been comprehensively synthesized. This study aims to analyze and synthesize scientific evidence on the effectiveness of core exercise in reducing work-related fatigue among workers through a systematic review method referring to the PRISMA 2020 guidelines. The literature search was planned to be conducted in the PubMed, Scopus, ScienceDirect, and Google Scholar databases using the PICOS framework, limited to primary experimental or quasi-experimental articles published between 2015 and 2025 in Indonesian and English. A preliminary search identified two studies that met the inclusion criteria, involving hospital nurses and factory workers, both of which reported a statistically significant reduction in work-related fatigue following core exercise or core stability exercise, with a training dose pattern of three times per week for six to eight weeks. Because of the limited number of studies at this stage, the synthesis is presented narratively and the conclusions are considered preliminary. These initial results indicate that core exercise has the potential to become an evidence-based intervention for reducing work-related fatigue; however, a formal literature search across all planned databases remains necessary to strengthen the evidence before it can be widely recommended in physiotherapy and occupational health practice.]]>
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