<![CDATA[Tuberculosis (TB) remains a major global health problem with high morbidity and mortality rates. The success of TB treatment is largely determined by patient adherence to anti-tuberculosis drug (OAT) therapy. One of the factors influencing adherence is the patient's level of knowledge regarding the disease and its treatment. This Study aimed to analyze the relationship between knowledge level and patient adherence to OAT therapy at Daruba Primary Health Center. This Study employed a quantitative design with a cross-sectional approach. A total of 43 respondents were selected using purposive sampling. Data were collected using questionnaires measuring knowledge level and adherence to OAT therapy and were analyzed using the chi-square test with a significance level of 0.05. The results showed that most respondents had moderate to good knowledge and moderate levels of adherence. Bivariate analysis revealed a significant relationship between knowledge level and adherence to OAT therapy (p < 0.05), indicating that respondents with better knowledge tended to be more adherent to treatment. In conclusion, there is a significant relationship between knowledge level and adherence to OAT therapy among tuberculosis patients. Adequate knowledge plays an important role in improving patient adherence to treatment. Therefore, structured and continuous educational interventions by healthcare providers are needed to enhance patient understanding and improve TB treatment outcomes. Adequate knowledge plays an important role in improving adherence to OAT therapy among TB patients. Continuous education is needed to improve knowledge and adherence among TB patients.]]>
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