Introduction: Sexualized drug use (SDU), known as chemsex or slamsex, is a growing phenomenon among gay, bisexual, and men who have sex with men (GBMSM). SDU is associated with an increased risk of HIV transmission and other adverse health outcomes. To further understand the trends, this study aimed to map the existing evidence on sexualized drug use among GBMSM and identify key research and practice gaps. Methods: A scoping review was used in this study. Inclusion criteria comprised peer-reviewed articles published in English that focused on SDU among GBMSM and reported health-related outcomes. The search strategy utilized online AI–assisted mapping through Connected Papers. 25 articles were included and analyzed using a descriptive analytical approach. The identified study designs included observational, reviews, and intervention. Results: There are several subtopics identified, including prevalence of users, type of drug, SDU practice/behaviors, biological effects, psychological effects, and prevention programs due to SDU. SDU among GBMSM demonstrated consistently high prevalence rates, particularly involving stimulants, which are used to enhance sexual experiences. These substances pose serious biological and psychological consequences, including an increased risk of HIV and other sexually transmitted infections, as well as mental health disorders. Conclusions: This review provides a comprehensive synthesis of SDU-related evidence among GBMSM while highlighting gaps in nursing- and public health–oriented interventions. SDU remains a critical public health issue among GBMSM with substantial health impacts. The findings underscore the need for culturally sensitive, nurse-led prevention, harm reduction, mental health support, and digital interventions to address SDU-related risks effectively.
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