Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Vol. 9 No. 2 (2025): Desember

PENGARUH SEDIAAN GEL EKSTRAK KULIT KAYU MATOA (Pometia pinnata) TERHADAP LUKA MEMAR PADA PAHA TIKUS (Rattus norvegicus)

Mahmud Sulthon Khoiruzaman (Universitas Pendidikan Muhmmadiyah Sorong)
A. M. Muslihin (Universitas Pendidikan Muhammadiyah Sorong)
Ratih Arum Astuti (Universitas Pendidikan Muhammadiyah Sorong)



Article Info

Publish Date
31 Dec 2025

Abstract

Matoa is a plant endemic to Papua, has antioxidant properties in its bark, which has the potential to treat bruises, a health problem that requires convenient product innovation. Thus, this study aims to test the effectiveness of matoa bark extract gel (Pometia pinnata) on bruises in white mice. This study is a quantitative experimental study. The gel was tested at extract concentrations of 1.5%, 3%, and 4.5%. Wound measurements were carried out using calipers, and observation notes were analyzed using two types of statistical tests: two types of paired and independent sample T-tests. The results showed that matoa bark extract contains saponins and flavonoids as antioxidants, anti-inflammatories, terpenoids that function as collagen stimulants. All treatment groups showed a significant healing effect. Gel concentrations of 3% and 4.5% gave significant results, although the 3% gel did not provide an effect equivalent to the positive control. The 1.5% gel had the same effect as the negative control. In conclusion, matoa bark extract gel with concentrations of 3% and 4.5% had a significant effect on healing bruises, although the 3% concentration of matoa bark extract gel did not provide an effect equivalent to the positive control.

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Journal Info

Abbrev

jurnal_farmasindo

Publisher

Subject

Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Description

The journal includes various fields of pharmaceuticals sciences such as: Pharmacy, Pharmacokinetics, Community and Clinical Pharmacy, Medical, Alternative medicines, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Microbiology, Tissue Culture, ...