The purpose of this study was to conduct a Systematic Literature Review (SLR) of research on the use of Articulate Storyline 3 as an interactive learning medium. This study aims to identify the characteristics of the application, analyze its effectiveness on student learning interest, learning motivation, and learning outcomes, and formulate its implications in supporting learning in the digital era. The study used a mixed methods with a Systematic Literature Review (SLR) approach. Research data were obtained from 15 scientific articles published in the period 2020–2025. The results of the study indicate that the use of Articulate Storyline 3 can improve the quality of learning, learning interest, learning motivation, and student learning outcomes. Based on the synthesis of data from the analyzed articles, an average media validity score of 87.68% was obtained, categorized as very appropriate. These findings indicate that Articulate Storyline 3 is an effective learning medium and is very appropriate for use in the learning process in schools to support improving the quality of education and creating more interactive and meaningful learning
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