THE ASSOCIATION BETWEEN PLATELET-TO-LYMPHOCYTE RATIO AND BONE MINERAL DENSITY IN REPRODUCTIVE-AGED WOMEN

Nanda Puspa Oktavianingrum (Undergraduate Student, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia)
Meita Hendrianingtyas (Dept of Clinical Pathology, Faculty of Medicine Universitas Diponegoro Semarang)
Edward Kurnia Setiawan Limijadi (Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia)
Farah Hendara Ningrum (Department of Radiology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia)

Jurnal Kedokteran Diponegoro
Vol 15, No 6 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)

Background: Bone Mineral Density (BMD) decreases in women aged 40–49 years. Platelet-Lymphocyte Ratio (PLR) is an inflammatory marker involved in the pathophysiology of osteoporosis. Objective: This study aimed to analyze the relationship between PLR and BMD in productive-age women for early osteoporosis risk detection. Method: This analytic observational study with a cross-sectional design included 107 medical records of productive-age women at Diponegoro National Hospital from March to September 2024, selected by consecutive sampling. The relationship between PLR and BMD was analyzed using the Spearman correlation test. Results: The analysis of Spearman correlation test showed that there was no significant relationship between PLR value and BMD value of spine L1 - L4 (p = 0.713; r = -0.036), PLR value and BMD value of left femur neck (p = 0.883; r = 0.014), and PLR value and BMD value of left femur total (p = 0.532; r = 0.061). Conclusion: There was no association between PLR and BMD of the L1–L4 spine, left femur neck, or left femur total; thus, it is not a marker of inflammation.