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All Journal Jurnal Kedokteran Diponegoro
Nanda Puspa Oktavianingrum
Undergraduate Student, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Medicine & Pharmacology

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THE ASSOCIATION BETWEEN PLATELET-TO-LYMPHOCYTE RATIO AND BONE MINERAL DENSITY IN REPRODUCTIVE-AGED WOMEN Nanda Puspa Oktavianingrum; Meita Hendrianingtyas; Edward Kurnia Setiawan Limijadi; Farah Hendara Ningrum
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 6 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i6.53542

Abstract

Background: Bone Mineral Density (BMD) decreases in women aged 40–49 years. Platelet-Lymphocyte Ratio (PLR) is an inflammatory marker involved in the pathophysiology of osteoporosis. Objective: This study aimed to analyze the relationship between PLR and BMD in productive-age women for early osteoporosis risk detection. Method: This analytic observational study with a cross-sectional design included 107 medical records of productive-age women at Diponegoro National Hospital from March to September 2024, selected by consecutive sampling. The relationship between PLR and BMD was analyzed using the Spearman correlation test. Results: The analysis of Spearman correlation test showed that there was no significant relationship between PLR value and BMD value of spine L1 - L4 (p = 0.713; r = -0.036), PLR value and BMD value of left femur neck (p = 0.883; r = 0.014), and PLR value and BMD value of left femur total (p = 0.532; r = 0.061). Conclusion: There was no association between PLR and BMD of the L1–L4 spine, left femur neck, or left femur total; thus, it is not a marker of inflammation.
Co-Authors Edward Kurnia Setiawan Limijadi Farah Hendara Ningrum Meita Hendrianingtyas