Patient comfort is an important need that requires attention during hospitalization and may be supported by adequate facilities and infrastructure as well as a conducive inpatient room environment. The implementation of the Standard Inpatient Class (KRIS) emphasizes the fulfillment of standardized inpatient facilities and infrastructure for participants of the National Health Insurance (JKN) program. However, the fulfillment of these standards does not necessarily reflect patients’ perceived comfort. This study aimed to analyze the effects of KRIS facilities and infrastructure and the inpatient room environment on patient comfort at RSIA Aisyiyah Pekajangan Pekalongan, both partially and simultaneously. This study employed a quantitative approach with a cross-sectional observational analytic design. A total of 82 inpatients were selected using purposive sampling. Data were collected using a Likert-scale questionnaire and analyzed using multiple linear regression, t-tests, F-tests, and the coefficient of determination. The results showed that KRIS facilities and infrastructure had a positive and significant effect on patient comfort (p=0.019; β=0.042). The inpatient room environment also had a positive and significant effect on patient comfort (p<0.001; β=1.124). Simultaneously, both variables had a significant effect on patient comfort (F=342.483; p<0.001). The adjusted R² value of 0.894 indicated that the two variables explained 89.4% of the variation in patient comfort, while the remaining 10.6% was explained by other factors. In conclusion, KRIS facilities and infrastructure and the inpatient room environment had positive and significant effects on patient comfort, both partially and simultaneously.
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